Best Life: Inflammatory sensors

HOUSTON, Texas (Ivanhoe Newswire) – It’s estimated more than seven million people in the U.S. and Europe will be diagnosed with inflammatory bowel disease by 2030.

That digestive disease triggers abdominal pain, diarrhea, and anemia. Now, lab research is focused on swallowing a bacterial biosensor that will pinpoint and transmit inflammation information to treat it more effectively.

“These are genes that have evolved inside of bacteria that sense molecules in the gut that are linked to inflammation,” said Jeffrey Tabor, Ph.D., a Professor of Bioengineering at Rice University.

Rice University researchers plan to take advantage of that with a platform delivery system to insert into the bacteria.

A capsule will deliver biosensors that monitor inflammation in the gut and transmit it to physicians for diagnosis of IBD.

It’s non-invasive and will transmit signals back to doctors regarding the patient’s level of inflammation.

“It took us about two years to find the first bacterial sensor. We were searching in bacterial genomes, analyzing their genes, discovering sensors of inflammation biomarkers, and then putting them back in bacteria and back in animals. You can think of a bacteria as a little sphere,” said Tabor.

The bacteria in the capsule have a little antenna outside the sphere that detects the molecule in the intestines.

“The molecule will, kind of, float into the antenna, stick to it, and turn the antenna on. And what this does is transmit the signal across the bacterial membrane, across the sphere, inside the bacteria itself,” said Tabor.

The bacterial sensors are connected to a green fluorescent protein and the bacteria will glow green, pinpointing the IBD inflammation. The biosensors are retrieved from the stool.

“We shine a blue light on them and if they glow green, we know that they’ve seen inflammation,” said Tabor.

Human clinical trials are three years out, but researchers who understand gut bacteria is the key to a cure, will use it to diagnose, eventually reducing the use of invasive tools like endoscopies and colonoscopies.

Contributors to this news report include: Donna Parker, Producer; Bruce Maniscalco, Videographer; Roque Correa, Editor.

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